Liquid risperidone in the treatment of rages in psychiatrically hospitalized children with possible bipolar disorder.
Liquid risperidone in the treatment of rages in psychiatrically hospitalized children with possible bipolar disorder.
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DOI：
10.1111/j.1399-5618.2010.00793.x
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发表时间：
2010-03
影响因子：
5.4
通讯作者：
Gutkovich Z
中科院分区：
文献类型：
--
作者：
Carlson GA;Potegal M;Margulies D;Basile J;Gutkovich Z
To examine the safety and efficacy of liquid risperidone to reduce duration of rages in children with severe mood dysregulation (SMD) or possible bipolar disorder (BP). There were 151 admissions of 5–12 year old children to a psychiatric inpatient unit. Diagnostic information and history of prior rages were obtained at admission. In hospital, a first rage outburst was treated with seclusion. If a 2nd rage occurred, the child was offered liquid risperidone to help him/her regain control. Risperidone dose was increased by 0.02 mg/kg for any successive rages. Duration of unmedicated and last medicated rage were compared. Rage frequency in children with SMD and several definitions of BP were compared. Although 82 of 151 admissions were prompted by rages, they occurred during only 49 hospitalizations, and occurred more than once in only 24. In 16 multiply-medicated children duration of rages dropped from a baseline of 44.4± 20.2 minutes to 25.6 ± 12.5 minutes at the child’s last dose. Neither SMD nor any definition of BP influenced rage response in this small sample. The average liquid risperidone dose was 0.02 mg/kg. All but 2 children also took atypical antipsychotics daily. No adverse events were observed. Liquid risperidone may be a safe and effective way to shorten the duration of rage episodes regardless of diagnosis. However, definitive conclusions cannot be drawn in the absence of a placebo control as children were also receiving other behavioral and psychopharmacologic treatments.
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DOI：
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发表时间：
2006-12-01
影响因子：
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DOI：
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发表时间：
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