Prevalence of metabolic syndrome and prediction of diabetes using IDF versus ATPIII criteria in a Middle East population
Prevalence of metabolic syndrome and prediction of diabetes using IDF versus ATPIII criteria in a Middle East population
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DOI：
10.1016/j.diabres.2012.09.037
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发表时间：
2012-12-01
影响因子：
5.1
通讯作者：
Shather, Zainab
中科院分区：
文献类型：
--
作者：
Hajat, Cother;Shather, Zainab
本研究利用基于人口的项目“Weqaya”的数据调查了阿布扎比代谢综合征的患病率和预测价值。 Weqaya 筛查包括心血管疾病 (CVD) 家族史、CVD 危险因素、随机血糖 (RBG) 和 HbA1c。既往没有糖尿病但糖尿病高危人群（RBG > 11.1 mmol/l 或 HbA1c > 6.1%）和随机选择的正常受试者进行空腹血糖、口服葡萄糖耐量试验（OGTT）、HbA1c 和空腹甘油三酯随访。在 760 名受试者中，325 名 (42.8%) 为男性，平均年龄为 41.9 岁 (SD 13.8)。根据世界卫生组织 (WHO) 的标准，149 人 (20.2%) 是新诊断的糖尿病患者。根据国际糖尿病基金会 (IDF) 和成人治疗小组 III (ATPIII) 标准，使用 OGTT 分析，非糖尿病患者中存在代谢综合征的比例为 29.0% vs. 31.5%，葡萄糖处理受损的比例为 63.4% vs. 64.2%，新发糖尿病患者的比例为 78.6% vs. 79.8% (P < .001)。 IDF 标准可以更好地预测糖尿病前期和糖尿病（分别为 OR 3.4 P < .001；OR 6.4 P < .001）； ATPIII 标准可以更好地预测高 CVD 风险评分 (OR 13.6 P < .001)。虽然 IDF 和 APTIII 定义提供了相似的患病率，但它们对糖尿病前期、糖尿病和 CVD 的预测存在差异。这项正在进行的研究将能够对该人群中糖尿病和心血管事件的发展进行纵向调查。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
This study investigates the prevalence and predictive value of metabolic syndrome in Abu Dhabi, using data from the population-based, programme, 'Weqaya'. The Weqaya screen included family history of cardiovascular disease (CVD), CVD risk factors, random blood glucose (RBG) and HbA1c. Those not previously diabetic but at high risk of diabetes (RBG > 11.1 mmol/l or HbA1c > 6.1%) and randomly selected normal subjects were followed-up with fasting glucose, oral glucose tolerance test (OGTT), HbA1c and fasting triglycerides. In 760 subjects, 325 (42.8%) were male with a mean age of 41.9 years (SD 13.8). Using World Health Organisation (WHO) criteria, 149 (20.2%) were newly diagnosed diabetics. Using International Diabetes Foundation (IDF) and Adult Treatment Panel III (ATPIII) criteria, metabolic syndrome was present in 29.0% vs. 31.5% of non-diabetics, 63.4% vs. 64.2% with impaired glucose handling and 78.6% vs. 79.8% with new-onset diabetes using OGTT (P < .001). IDF criteria better predicted pre-diabetes and diabetes (OR 3.4 P < .001; OR 6.4 P < .001, respectively); ATPIII criteria better predicted high CVD risk scores (OR 13.6 P < .001). Whilst IDF and APTIII definitions provide similar prevalence rates, they differentially predict prediabetes, diabetes and CVD. This ongoing study will enable the longitudinal investigation of the development of diabetes and cardiovascular events in this population. (C) 2012 Elsevier Ireland Ltd. All rights reserved.