Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected children.
Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected children.
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HIV感染儿童接种减毒活疫苗或灭活流感疫苗后抗流感血清和粘膜抗体反应。
DOI：
10.1097/qai.0b013e3181e46308
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
IMPAACTP1057Team
中科院分区：
文献类型：
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作者：
Weinberg,Adriana;Song,Lin-Ye;Walker,Robert;Allende,Maria;Fenton,Terence;Patterson-Bartlett,Julie;Nachman,Sharon;Kemble,George;Yi,Ting-Ting;Defechereux,Patricia;Wara,Diane;Read,JenniferS;Levin,Myron;IMPAACTP1057Team
背景：与三价灭活疫苗(TIV)相比，减毒活疫苗(LAIV)可预防更多免疫能力儿童的流感病例。方法：对243例HIV感染儿童随机分为TIV组和LAIV组，分析免疫后4周和24周的血液和唾液中和抗体水平。结果：两种疫苗免疫后4周和24周均有抗流感中和抗体产生。在免疫后4周，TIV接受者的中和抗体滴度是LAIV接受者的2-3倍，但保护性滴度(≥1：40)的受试者比例在治疗组之间相似(甲型流感96%-100%，乙型流感81%-88%)。两种疫苗都能增加唾液同型免疫球蛋白抗体，但不能增加免疫球蛋白A抗体。这两种疫苗也都增加了血清异型抗体。在HIV特异性特征中，基线病毒载量与对任何一种疫苗的抗体反应相关性最好。我们使用LAIV病毒脱落作为流感感染的替代品。未脱毛者的流感特异性体液和粘膜抗体水平显著高于脱毛者。结论：LAIV和TIV在HIV感染的儿童中产生同型和异亚型的体液和黏膜抗体应答。高滴度的体液或粘膜抗体与防止病毒脱落有关。
Background:Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children.Methods:Blood and saliva obtained at enrollment, 4 and 24 weeks postimmunization from 243 HIV-infected children randomly assigned to TIV or LAIV were analyzed.Results:Both vaccines increased the anti-influenza neutralizing antibodies at 4 and 24 weeks postimmunization. At 4 weeks postimmunization, TIV recipients had 2-fold to 3-fold higher neutralizing antibody titers than LAIV recipients, but the proportions of subjects with protective titers (≥ 1: 40) were similar between treatment groups (96%-100% for influenza A and 81%-88% for influenza B). Both vaccines increased salivary homotypic IgG antibodies, but not IgA antibodies. Both vaccines also increased serum heterosubtypic antibodies. Among HIV-specific characteristics, the baseline viral load correlated best with the antibody responses to either vaccine. We used LAIV-virus shedding as a surrogate of influenza infection. Influenza-specific humoral and mucosal antibody levels were significantly higher in nonshedders than in shedders.Conclusions:LAIV and TIV generated homotypic and heterosubtypic humoral and mucosal antibody responses in HIV-infected children. High titers of humoral or mucosal antibodies correlated with protection against viral shedding.