Role of RNA secondary structures in regulating Dscam alternative splicing
Role of RNA secondary structures in regulating Dscam alternative splicing
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RNA二级结构在调节Dscam选择性剪接中的作用
DOI：
10.1016/j.bbagrm.2019.04.008
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发表时间：
2019-11-01
影响因子：
4.7
通讯作者：
Jin，Yongfeng
中科院分区：
文献类型：
--
作者：
Xu，Bingbing;Shi，Yang;Jin，Yongfeng
mRNA前体的选择性剪接是扩大蛋白质组多样性的通用机制。最引人注目的例子是果蝇唐氏综合症细胞粘附分子（Dscam 1）基因，它通过互斥剪接可能编码38,016种不同的同种型。Dscam 1的基因组结构在泛甲壳动物中很大程度上是保守的，尽管剪接异构体的数量从蛤虾（Eulimnadia texana）的2240到南美白对虾（Litopenaeus vannamei）的121，104不等。RNA二级结构在Dscam 1的互斥剪接中起着关键作用。本文综述了RNA二级结构在Dscam 1选择性剪接中的识别、进化和调控作用的最新进展。
Alternative splicing of mRNA precursors is a versatile mechanism of expanding proteomic diversity. The most striking example of this is theDrosophila melanogasterDown syndrome cell adhesion molecule(Dscam1) gene, which potentially encodes 38,016 distinct isoforms by mutually exclusive splicing. The genomic organization ofDscam1is largely conserved across the pancrustaceans, although the number of splice isoforms varies from 2240 in the clam shrimp (Eulimnadia texana) to 121,104 in the whiteleg shrimp (Litopenaeus vannamei). RNA secondary structure plays a pivotal role in mutually exclusive splicing ofDscam1. Here, we review recent progress in the identification, evolution, and regulatory roles of RNA secondary structure in alternative splicing ofDscam1.