Analyzing 180 degrees turns using an inertial system reveals early signs of progression of Parkinson's disease.
Analyzing 180 degrees turns using an inertial system reveals early signs of progression of Parkinson's disease.
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DOI：
10.1109/iembs.2009.5333970
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Aminian K
中科院分区：
文献类型：
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作者：
Salarian A;Zampieri C;Horak FB;Carlson-Kuhta P;Nutt JG;Aminian K
转动能力的改变是帕金森病 (PD) 的早期运动缺陷之一。我们提出了一种基于可穿戴惯性传感器和新颖的自动分析算法的系统，可以评估 180° 转弯。本研究纳入了 12 名 PD 早期患者和 14 名年龄匹配的健康受试者。惯性传感器安装在小腿和胸骨上。测量方案包括在笔直路径上行走、转向 180° 然后返回。在 18 个月的时间内，对受试者进行了 4 次测量，每 6 个月测量一次。在基线时，每组 9 名受试者重复测试两次，以评估重测可靠性。轻度 PD 患者的姿势不稳定性步态困难（UPDRS III 的 PIGD 子评分）评分非常低（平均 0.67，最小值 0，最大值 3）。分析显示，患者的转身持续时间显着更长（2.18±0.43 vs. 1.79±0.27，p<0.02），并且在开始转身之前最后一步的延迟时间更长（0.56±0.04 vs. 0.52±0.04，p<0.03）。估计的转弯持续时间和其他指标具有较高的重测可靠性（ρ>0.85）。在纵向研究中，翻身持续时间也显示出显着的组*时间交互作用（p<0.03），突出了疾病进展的早期迹象。
Changes in turning are one of the early motor deficiencies in Parkinson’s Disease (PD). We have proposed a system based on wearable, inertial sensors and a novel automatic analysis algorithm that can assess 180° turns. Twelve patients in early stages of PD and 14 age-matched healthy subjects were enrolled in this study. Inertial sensors were attached on shanks and sternum. Measurement protocol included walking on a straight pathway, turning 180° and returning back. Subjects were measured 4 times, once every 6 months during an 18 months period. At the baseline, 9 subject from each group repeated the test twice to assess test-retest reliability. Patients with mild PD had a very low Postural Instability Gait Difficulty (PIGD subscore of UPDRS III) score (average 0.67, min 0, max 3). The analysis showed that the patients had a significantly longer turning duration (2.18±0.43 vs. 1.79±0.27, p<0.02) and higher delay in their last step before initiating a turn (0.56±0.04 vs. 0.52±0.04, p<0.03). Estimated turning duration and other metrics had a high test-retest reliability (ρ>0.85). Turning duration also showed a significant Group*Time interaction (p<0.03) during the longitudinal study highlighting early signs of the progression of the disease.