Novel regulator of vasopressin secretion: phoenixin
Novel regulator of vasopressin secretion: phoenixin
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DOI：
10.1152/ajpregu.00426.2017
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发表时间：
2018-04-01
影响因子：
2.8
通讯作者：
Samson, Willis K.
中科院分区：
文献类型：
--
作者：
Gasparini, Silvia;Stein, Lauren M.;Samson, Willis K.
新发现的下丘脑肽。下丘脑和腺垂体中产生凤凰素，在那里它控制生殖激素分泌。phoenixin及其受体GPR 173均在下丘脑视上核（SON）和室旁核（PVN）中表达，表明该肽控制加压素（AVP）或催产素（OT）分泌的额外非生殖作用。下丘脑-神经垂体外植体释放AVP，但不响应凤凰毒素OT。侧脑室注射凤凰霉素到清醒，不受限制的男性和女性大鼠显着增加循环AVP，但不是OT，血浆中的水平，它增加了立即早期基因表达的雄性大鼠视上核。浴应用phocnixin在下丘脑切片制备导致PVN神经元的去极化，表明phocnixin在下丘脑中的直接神经作用。我们的研究结果表明，新描述的，下丘脑肽phoenixin，除了其对下丘脑和垂体控制生殖机制的影响，可能有助于调节液体和电解质稳态的生理机制。
The newly described hypothalamic peptide. phoenixin, is produced in the hypothalamus and adenohypophysis, where it acts to control reproductive hormone secretion. Both phoenixin and its receptor GPR173 are expressed in the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei, suggesting additional, nonreproductive effects of the peptide to control vasopressin (AVP) or oxytocin (OT) secretion. Hypothalamo-neurohypophysial explants released AVP but not OT in response to phoenixin. Intracerebroventricular administration of phoenixin into conscious, unrestrained male and female rats significantly increased circulating AVP, but not OT, levels in plasma, and it increased immediate early gene expression in the supraoptic nuclei of male rats. Bath application of phocnixin in hypothalamic slice preparations resulted in depolarization of PVN neurons, indicating a direct, neural action of phoenixin in the hypothalamus. Our results suggest that the newly described, hypothalamic peptide phoenixin, in addition to its effects on hypothalamic and pituitary mechanisms controlling reproduction, may contribute to the physiological mechanisms regulating fluid and electrolyte homeostasis.