rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy
rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy
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DOI：
10.1128/jcm.37.4.1197-1199.1999
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发表时间：
1999-04-01
影响因子：
9.4
通讯作者：
Orefici, G
中科院分区：
文献类型：
--
作者：
Pozzi, G;Meloni, M;Orefici, G
研究了在意大利分离的37株结核分枝杆菌多药耐药（MDR）临床菌株中与利福平耐药相关的rpoB突变。每个MDR株至少有一个突变密码子。它总是一个单碱基取代导致氨基酸的变化。结果发现9种rpoB等位基因，其中3种为首次报道，其相对突变频率与不同地区报道的rpoB等位基因不同，其中22株（59.5%）在531位密码子TTG突变（Ser → Leu），11株（29.7%）在526位密码子GAC突变（His → Asp）。
Mutations of rpoB associated with rifampin resistance were studied in 37 multidrug-resistant (MDR) clinical strains of Mycobacterium tuberculosis isolated in Italy. At least lone mutated codon was found in each MDR strain. It was always a single-base substitution leading to an amino acid change. Nine different rpoB alleles, three of which had not been reported before, were found. The relative frequencies of specific mutations in this sample were different from those previously reported from different geographical areas, since 22 strains (59.5%) carried the mutated codon TTG in position 531 (Ser-->Leu) and 11 (29.7%) had GAC in position 526 (His-->Asp).