Computational optical biopsy.
Computational optical biopsy.
复制标题
DOI：
10.1186/1475-925x-4-36
复制
发表时间：
2005-06-14
影响因子：
3.9
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Li Y;Jiang M;Wang G
光学分子成像基于荧光或生物发光，并且受到组织中光子散射的阻碍，特别是在患者研究中。在这里，我们提出了一种计算光学活检（COB）的方法来定位和量化的光源深处的一个主题。与现有的光学活检技术相比，我们的方案是直接从受试者体内的感兴趣区域沿着一个或多个活检路径收集光学信号，然后计算底层光源分布的特征。在本文中，我们制定了这个反问题的扩散近似的框架下，证明在两个代表性的配置的解决方案的唯一性，并获得解析解的光学性质和源参数的重建。
Optical molecular imaging is based on fluorescence or bioluminescence, and hindered by photon scattering in the tissue, especially in patient studies. Here we propose a computational optical biopsy (COB) approach to localize and quantify a light source deep inside a subject. In contrast to existing optical biopsy techniques, our scheme is to collect optical signals directly from a region of interest along one or multiple biopsy paths in a subject, and then compute features of an underlying light source distribution. In this paper, we formulate this inverse problem in the framework of diffusion approximation, demonstrate the solution uniqueness properties in two representative configurations, and obtain analytic solutions for reconstruction of both optical properties and source parameters.