Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats
Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats
复制标题
DOI：
10.3177/jnsv.50.9
复制
发表时间：
2004-02-01
影响因子：
1.6
通讯作者：
Yamada, K
中科院分区：
文献类型：
--
作者：
Hirao, A;Yamasaki, M;Yamada, K
我们研究了饮食共轭亚油酸（CLA）对Sprague-Dawley大鼠部分肝切除术（PH）后肝再生的影响。对喂食0或1重量%的CLA饮食3周。平均肝脏重量在CLA喂养大鼠人口是比对照组大鼠人口在PH和PH后1天的时间。相反，CLA喂养大鼠的肝脏重量显着低于对照组大鼠在PH后7天。这表明，饮食CLA减少肝脏重量增加后PH。饮食CLA不影响血清天冬氨酸转氨酶（AST）或丙氨酸转氨酶（ALT）的活动。然而，CLA显着降低血清白蛋白水平，在1-d，但不是在7天后PH。5-溴-和5-碘脱氧尿苷掺入肝细胞PH后1-d的CLA组较低。总之，数据表明，膳食CLA抑制PH后的DNA合成，这导致肝细胞增殖抑制。
We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat population was heavier than the control rat population at the time of PH and 1-d after PH. Conversely, CLA fed rats' liver weight was significantly lower than control rats at 7-d after PH. This suggests that dietary CLA reduced liver weight gain after PH. Dietary CLA did not affect serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. However, CLA significantly reduced serum albumin levels at 1-d but not at 7-d after PH. 5-Bromo- and 5-iododeoxyuridine incorporation into hepatocytes 1-d post PH was lower in the CLA group. In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition.