Dynamic changes in the cortico-subcortical network during early motor learning
Dynamic changes in the cortico-subcortical network during early motor learning
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DOI：
10.3233/nre-2010-0540
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发表时间：
2010-01-01
影响因子：
2
通讯作者：
Kim, Sung Tae
中科院分区：
文献类型：
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作者：
Park, Ji-Won;Kim, Yun-Hee;Kim, Sung Tae
背景：由于该过程中涉及的任何大脑区域受损而导致早期运动学习失败，可能会干扰此类患者的成功康复。目的：我们研究了顺序手指运动学习过程中运动网络激活的变化，以描绘运动技能学习过程中皮质-皮质下网络的特征。方法：20 名健康的右手志愿者参与。受试者被要求执行八个连续的手指运动任务，同时进行功能性 MRI (fMRI)。 结果：随着时间的推移，参与者的表现从第 1 块到第 4 块有所改善，表明已经成功学习，随后从第 5 块到最后一个块达到平稳状态。在fMRI上，对侧初级感觉运动皮层、前运动皮层、辅助运动区和后顶叶皮层的活动从区块1到区块4逐渐增加，然后从区块5到最后逐渐减少。相反，同侧小脑的活动显示出跨越最后一个区块的线性增加，并达到峰值激活。丘脑和基底神经节在运动学习的独特阶段表现出单侧或双侧活动。结论：这些发现描绘了运动学习和自动化早期阶段皮质-皮质下网络的特征性可塑性变化和不同作用。
Background: Failure of early motor learning due to damage in any brain area involved in this process may interfere with successful rehabilitation of such patients.Objective: We investigated the changes in activation of the motor network during sequential finger motor learning to delineate the characteristics of the cortico-subcortical network during motor skill learning.Methods: Twenty healthy, right-handed volunteers participated. Subjects were instructed to perform eight blocks of a sequential finger motor task while functional MRI (fMRI) was performed.Results: The participants had an improvement in performance over time from block 1 to block 4, indicating that successful learning had occurred, followed by a plateau from block 5 to the last block. On fMRI, activities of the contralateral primary sensorimotor cortex, the premotor cortex, the supplementary motor area, and the posterior parietal cortex gradually increased from block 1 to block 4 and then decreased from block 5 to the last. In contrast, activity of the ipsilateral cerebellum showed a linear increase spanning the last block with peak activation. The thalamus and basal ganglia showed unilateral or bilateral activities at the unique stage of motor learning.Conclusions: These findings delineated the characteristic plastic changes and different roles of the cortico-subcortical network during the early phase of motor learning and automatization.