A prospective study of nocturia and the quality of life of elderly patients with obstructive sleep apnea or sleep onset insomnia
A prospective study of nocturia and the quality of life of elderly patients with obstructive sleep apnea or sleep onset insomnia
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DOI：
10.1016/s0022-3999(04)00021-2
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发表时间：
2004-05-01
影响因子：
4.7
通讯作者：
Ramos, E
中科院分区：
文献类型：
--
作者：
Guilleminault, C;Lin, CM;Ramos, E
目的：前瞻性评估无导致睡眠呼吸暂停增加的泌尿系统和医疗条件的老年患者中阻塞性睡眠呼吸暂停综合征（OSAS）、睡眠呼吸暂停与生活质量之间的关系。方法：对65岁及以上的男性单纯OSAS或睡眠发作性失眠患者进行前瞻性研究。采用埃普沃思嗜睡量表（ESS）、贝克抑郁量表（BDI）、生活质量量表（SF-36）进行评定。结果如下：OSAS患者中，频繁排尿者的体重指数（BMI）、呼吸暂停低通气指数（AHI）、最低血氧饱和度和SF-36评分均显著高于正常对照组。经鼻持续气道正压通气（CPAP）治疗OSAS和行为技术治疗失眠改善了所有三组的ESS和BDI评分。SF-36子量表评分在患有多发性精神障碍的受试者中改善更多。AHI和BMI可以解释肥胖症38%的变异。结论：经鼻持续气道正压通气可减少老年患者的阻塞性睡眠呼吸暂停（OSA）和排尿困难，提高生活质量。(C)2004年爱思唯尔公司All rights reserved.
Objective: To prospectively evaluate the relationship between obstructive sleep apnea syndrome (OSAS), nocturia and quality of life in elderly patients free of the urologic and medical conditions that lead to increased nocturia. Methods: Prospective study of nocturia in men 65 years and older with isolated OSAS or sleep onset insomnia. After a 7-day nocturia evaluation and nocturnal polysomnoggaphy, Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), Quality of Life (SF-36) were administered. Results: OSAS patients with frequent nocturia had significantly greater body mass index (BMI), greater apnea-hypopnea index (AHI), lower lowest oxygen saturation and lower SF-36 subscale scores. Treatment with nasal continuous positive airway pressure (CPAP) for OSAS and behavioral techniques for insomnia improved ESS and BDI scores for all three groups. SF-36 subscale scores improved more in subjects with multiple nocturia. AHI and BMI explain 38% of the variance for nocturia. Conclusion: Nasal CPAP reduces OSA and nocturia and improves quality of life of elderly patients. (C) 2004 Elsevier Inc. All rights reserved.