Epidemiology and etiology of cardiomyopathy in Africa
Epidemiology and etiology of cardiomyopathy in Africa
复制标题
DOI：
10.1161/circulationaha.105.542894
复制
发表时间：
2005-12-06
期刊：
影响因子：
37.8
通讯作者：
Mayosi, BM
中科院分区：
文献类型：
--
作者：
Sliwa, K;Damasceno, A;Mayosi, BM
背景--心肌病是一种不可逆的心肌疾病，预后不良，是非洲的地方病。本次审查的主要目的是总结目前的流行病学和心肌病的病因学在生活在Africa的人的知识状态，并确定新的途径research.Methods和结果-我们搜索MEDLINE（1966年1月1日，通过2005年2月12日）和相关参考文献的文章列表。与世界其他地区心肌病罕见不同，扩张型心肌病是整个非洲心力衰竭的主要原因。同样，围产期心肌病在非洲大陆普遍存在，发病率从1/100到1/1000不等。扩张型心肌病和围产期心肌病的发病机制存在明显的区域差异，强调了这些疾病致病因素的异质性。相比之下，肌内膜纤维化仅限于东非、中非和西非的热带地区。虽然子宫内膜异位症纤维化的发病机制尚未完全清楚，但似乎条件因素是地理和饮食，触发因素可能是一种尚未确定的感染因子，而永久性因素是嗜酸性粒细胞增多症。虽然流行病学研究是缺乏的，肥厚型心肌病和致动脉粥样硬化性右心室心肌病似乎有类似的特点，在世界其他地方的其他人群在world.Conclusions -有必要进行大规模的流行病学研究的发病率，患病率，决定因素和心肌病在非洲的结果，告知战略的治疗和预防心肌疾病在非洲大陆。
Background - Cardiomyopathy, an often irreversible form of heart muscle disease that is associated with a dismal outcome, is endemic in Africa. The primary objective of this review was to summarize the current state of knowledge on the epidemiology and etiology of cardiomyopathy in people living in Africa and to identify new avenues for research.Methods and Results - We searched MEDLINE (January 1, 1966, through February 12, 2005) and reference lists of articles for relevant references. Unlike other parts of the world in which cardiomyopathy is rare, dilated cardiomyopathy is a major cause of heart failure throughout Africa. Similarly, peripartum cardiomyopathy is ubiquitous on the continent, with an incidence ranging from 1 in 100 to 1 in 1000 deliveries. There is an apparent marked regional variation in the pathogenesis of dilated cardiomyopathy and peripartum cardiomyopathy, underlining the heterogeneity of causative factors in these conditions. By contrast, endomyocardial fibrosis is restricted to the tropical regions of East, Central, and West Africa. Although the pathogenesis of endomyocardial fibrosis is not fully understood, it seems that the conditioning factors are geography and diet, the triggering factor may be an as yet unidentified infective agent, and the perpetuating factor is eosinophilia. Although epidemiological studies are lacking, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy seem to have characteristics similar to those of other populations elsewhere in the world.Conclusions - There is a need for large-scale epidemiological studies of the incidence, prevalence, determinants, and outcome of cardiomyopathy in Africa to inform strategies for the treatment and prevention of heart muscle disease on the continent.