Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness.
Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness.
复制标题
DOI：
10.1097/iae.0b013e3181bd2c3b
复制
发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Duker JS
中科院分区：
文献类型：
--
作者：
Sull AC;Vuong LN;Price LL;Srinivasan VJ;Gorczynska I;Fujimoto JG;Schuman JS;Duker JS
为了报告正常黄斑厚度测量值并评估通过时域光学相干断层扫描（OCT）（Stratus [Carl Zeiss Meditec，Inc.，都柏林，CA，USA]）和三种市售光谱/傅立叶域OCT仪器（Cirrus HD-OCT [Carl Zeiss Meditec，Inc.，都柏林，CA，美国]，RTVue-100 [Optovue，Inc.，Fremont，CA，USA]，3D OCT-1000 [Topcon，Inc.，Paramus，NJ，USA]）。随机选择40名正常健康志愿者的40只眼睛进行成像。受试者在一次访视期间扫描两次，25名受试者的子集在8周内再次扫描。通过OCT软件自动生成视网膜厚度测量值，并在手动校正后记录。使用回归和Bland-Altman图比较仪器之间的一致性。使用组内相关系数（ICC）分析再现性，并确定伪影的发生率。发现所有仪器的黄斑厚度测量具有较高的重现性，Stratus OCT的ICC值范围为84.8-94.9%; Cirrus Cube为92.6-97.3%; RTVue MM 5为76.4-93.7%，MM 6为61.1-96.8%; 3D OCT-1000径向为93.1-97.9%，3D黄斑扫描为31.5-97.5%。伪影的发生率较高的频谱/傅立叶域仪器，范围为28.75%至53.16%，相比之下，17.46%的Stratus OCT。没有显着的年龄或性别的趋势，发现在测量。商业光谱/傅立叶域OCT仪器提供比Stratus OCT更高的速度和轴向分辨率，尽管它们在扫描协议方面差异很大，并且目前在其分析功能方面受到限制。需要进一步开发分割算法和定量特征，以帮助临床医生客观地使用这些新仪器来管理疾病。
To report normal macular thickness measurements and assess reproducibility of retinal thickness measurements acquired by a time domain optical coherence tomography (OCT)(Stratus [Carl Zeiss Meditec, Inc., Dublin, CA, USA]) and three commercially available spectral / Fourier domain OCT instruments (Cirrus HD-OCT [Carl Zeiss Meditec, Inc., Dublin, CA, USA], RTVue-100 [Optovue, Inc., Fremont, CA, USA], 3D OCT-1000 [Topcon, Inc., Paramus, NJ, USA]). Forty randomly selected eyes of 40 normal, healthy volunteers were imaged. Subjects were scanned twice during one visit and a subset of 25 was scanned again within 8 weeks. Retinal thickness measurements were automatically generated by OCT software and recorded after manual correction. Regression and Bland-Altman plots were used to compare agreement between instruments. Reproducibility was analyzed by using intraclass correlation coefficients (ICC), and incidence of artifacts was determined. Macular thickness measurements were found to have high reproducibility across all instruments, with ICC values ranging 84.8–94.9% for Stratus OCT; 92.6–97.3% for Cirrus Cube; 76.4–93.7% for RTVue MM5, 61.1–96.8% for MM6; 93.1–97.9% for 3D OCT-1000 Radial, 31.5–97.5% for 3D Macular scans. Incidence of artifacts was higher in spectral / Fourier domain instruments, ranging 28.75 to 53.16%, compared to 17.46% in Stratus OCT. No significant age or gender trends were found in the measurements. Commercial spectral / Fourier domain OCT instruments provide higher speed and axial resolution than the Stratus OCT, although they vary greatly in scanning protocols and are currently limited in their analysis functions. Further development of segmentation algorithms and quantitative features are needed to assist clinicians in objective use of these newer instruments to manage diseases.