Otolith ocular reflex function of the tangential nucleus in teleost fish
Otolith ocular reflex function of the tangential nucleus in teleost fish
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DOI：
10.1111/j.1749-6632.1999.tb09171.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Baker, R
中科院分区：
文献类型：
--
作者：
Suwa, H;Gilland, E;Baker, R
在硬骨鱼中，切向核可以被识别为位于前庭复合体中部附近的VIIIth神经腹侧的一个紧密的、独立的细胞群。用生物细胞素和荧光示踪剂对幼虫和成虫后脑进行的形态分析表明，切向核完全位于菱形体节段5内，所有轴突都投射到对侧MLF。结合单细胞电生理学和形态学，在警觉的金鱼中发现了三类神经元，其生理敏感性可以很容易地与围绕前(45度)、后(135度)或水平(垂直轴)半规管的旋转轴相关。切向神经元与半规管特定亚核的区别在于其自发背景为10-15SP/S，在+/-4度头部移位后仍保持静态敏感性。每一轴特定的切线亚型都适当地终止于负责垂直、扭转或水平眼球运动的动眼神经亚核，在少数情况下，轴突侧支在MLF向脊髓下降。因此，我们假设，切向核由3个特定于轴的表型组成，它们处理重力惯性信号，主要负责控制眼球运动功能，但也部分负责维持身体姿势。
In teleost fish, the tangential nucleus can be identified as a compact, separate cell group lying ventral to the VIIIth nerve near the middle of the vestibular complex. Morphological analysis of larval and adult hindbrains utilizing biocytin and fluorescent tracers showed the tangential nucleus to be located entirely within rhombomeric segment 5 with all axons projecting into the contralateral MLF. Combined single-cell electrophysiology and morphology in alert goldfish found three classes of neurons whose physiological sensitivity could be readily correlated with rotational axes about either the anterior (45 degrees), posterior (135 degrees), or horizontal (vertical axis) semicircular canals. Tangential neurons could be distinguished from those in semicircular-canal specific subnuclei by an irregular, spontaneous background of 10-15 sp/s and sustained static sensitivity after +/-4 degrees head displacements. Each axis-specific tangential subtype terminated appropriately onto oculomotor subnuclei responsible for either vertical, torsional, or horizontal eye movements and, in a few cases, axon collaterals descended in the MLF toward the spinal cord. We hypothesize, therefore, that the tangential nucleus consists of 3 axis-specific phenotypes that process gravitoinertial signals largely responsible for controlling oculomotor function, but that also in part, maintain body posture.