Stem Cells
Stem Cells
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DOI：
10.1196/annals.1434.010
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发表时间：
2008-04
影响因子：
5.2
通讯作者：
O. Oktem;K. Oktay
中科院分区：
文献类型：
--
作者：
O. Oktem;K. Oktay
干细胞具有无限的自我更新功能以及分化为体内几乎所有成熟细胞类型的能力，在研究和治疗应用方面具有巨大的潜力。在这篇文章中，我们回顾了原始生殖细胞的形成，成年配子母细胞的前体，从他们的规格，他们的迁移到未来的性腺。我们讨论了最近的研究，获得生殖细胞的干细胞在体外。我们特别强调的研究，挑战生殖生物学目前的教条，雌性哺乳动物出生时，在卵巢中的生殖细胞更新显示在成年卵巢的一组数量的不可再生的生殖细胞。
Stem cells, with their unlimited self‐renewal feature and their ability to differentiate into almost every mature cell type in the body, have enormous potential for research and therapeutic application. In this article, we review the formation of primordial germ cells, the precursors of adult gametocytes, from their specification to their migration to prospective gonads. We discuss recent studies that obtained germ cells from stem cells in vitro. We place special emphasis on studies that challenge the current dogma in reproductive biology that female mammals are born with a set number of nonrenewable germ cells in the ovary by showing germ cell renewal in the adult ovary.