Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy.
Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy.
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血小板生成素：妊娠期免疫性血小板减少症的潜在诊断指标
DOI：
10.18632/oncotarget.7106
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发表时间：
2016-02-16
期刊：
影响因子：
--
通讯作者：
Hou M
中科院分区：
文献类型：
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作者：
Zhang X;Zhao Y;Li X;Han P;Jing F;Kong Z;Zhou H;Qiu J;Li L;Peng J;Hou M
评估妊娠相关免疫性血小板减少症（ITP）与妊娠期血小板减少症的血清血小板生成素水平是否存在差异，并揭示血小板生成素作为鉴别诊断标志物的可能性。通过 ELISA 测定妊娠 ITP（n = 35）、妊娠血小板减少症（n = 31）、健康妊娠（n = 32）、年龄匹配的非妊娠 ITP（n = 32）和非妊娠健康对照（n = 35）的血清血小板生成素浓度。妊娠期ITP的血清血小板生成素水平（1283±646pg/mL）显着高于妊娠期血小板减少症（187±64pg/mL）（P<0.01），尽管这两种疾病的血小板计数可能重叠。 35 名妊娠期 ITP 患者中，有 29 名血小板生成素值 >500 pg/mL，而妊娠期血小板减少症患者的血小板生成素水平均未超过 500 pg/mL。此外，妊娠期ITP的血小板生成素水平显着高于非妊娠期ITP（88±41 pg/mL）（P < 0.01），表明妊娠期和非妊娠期ITP的发病机制不同。我们的研究结果表明，血清血小板生成素浓度的测量为区分妊娠期 ITP 和妊娠期血小板减少症提供了有价值的诊断信息。血小板生成素是妊娠期 ITP 的可靠标志物。
To evaluate whether the serum thrombopoietin levels in pregnancy-associated immune thrombocytopenia (ITP) differ from those in gestational thrombocytopenia, and reveal the possibility of thrombopoietin serving as a marker for differential diagnosis. Serum thrombopoietin concentration was determined in ITP in pregnancy (n = 35), gestational thrombocytopenia (n = 31), healthy pregnancy (n = 32), age-matched nonpregnant ITP (n = 32) and nonpregnant healthy controls (n = 35) by ELISA. The serum thrombopoietin level of ITP in pregnancy (1283 ± 646 pg/mL) was significantly higher than gestational thrombocytopenia (187 ± 64 pg/mL) (P < 0.01), although the platelet counts of these two disorders may overlap. Twenty-nine of 35 patients with ITP in pregnancy had thrombopoietin values >500 pg/mL, whereas none of the gestational thrombocytopenia patients' thrombopoietin levels exceeded 500 pg/mL. In addition, ITP in pregnancy presented a markedly higher thrombopoietin level than nonpregnant ITP (88 ± 41 pg/mL) (P < 0.01), indicating that the pathogenesis of pregnant and nonpregnant ITP was different. Our findings suggest that measurement of serum thrombopoietin concentration provides valuable diagnostic information for differentiating ITP in pregnancy from gestational thrombocytopenia. Thrombopoietin represents a reliable marker for ITP in pregnancy.