High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis
High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis
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miR-210 的高表达预测乳腺癌患者的生存率较差：一项荟萃分析。
DOI：
10.1016/j.gene.2012.07.025
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发表时间：
2012-10-10
期刊：
影响因子：
3.5
通讯作者：
Syed, Labiq
中科院分区：
文献类型：
--
作者：
Hong, Liu;Yang, Jianjun;Syed, Labiq
背景资料：许多microRNA（miRNAs）在癌症中表现出改变的表达水平，并且它们可以被认为是癌症的有价值的预后生物标志物。方法：检索PubMed、科克伦图书馆和Science Direct数据库，对miR-210在乳腺癌中的作用进行Meta分析。数据提取自比较具有较高miR-210表达的乳腺癌患者与具有较低miR-210表达的乳腺癌患者的存活率的研究。结果：共纳入511例乳腺癌患者，进行了总体荟萃分析。对于术后生存率，乳腺癌组织中miR-210高表达的HR为3.39（95%CI：2.04-5.63，P
Background: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.Methods: A meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.Results: A total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% Cl: 2.04-5.63, P