Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population
Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population
复制标题
DOI：
10.1111/liv.13743
复制
发表时间：
2018-11-01
影响因子：
6.7
通讯作者：
Buscemi, Silvio
中科院分区：
文献类型：
--
作者：
Petta, Salvatore;Di Marco, Vito;Buscemi, Silvio
背景与目标肥胖症在全球范围内的蔓延导致非酒精性脂肪性肝病 (NAFLD) 及其并发症的患病率急剧增加。我们的目的是评估地中海地区一般人群中与 NAFLD 相关的患病率和因素。方法结果我们考虑了基于社区的 ABCD（Alimentazione、Benesser Cardiovascolare e Diabete）研究 (ISRCTN15840340) 中连续 890 名个体。使用 FibroScan 测量受控衰减参数 (CAP) 和肝脏硬度测量 (LSM)。对参与者进行了 PNPLA3 rs738409 和 TM6SF2 rs58542926 变异的基因分型。队列中 NAFLD 的患病率为 48%。 NAFLD 参与者的 LSM 值升高，表明晚期纤维化（6.5% 的病例）。 NAFLD 和晚期纤维化均与传统危险因素独立相关（NAFLD：年龄 >50 岁、肥胖、高血压、ALT 升高和低 HDL 胆固醇血清浓度。晚期纤维化：IFG/糖尿病、ALT 血清浓度升高）。肥胖人群中 NAFLD 的患病率较高（>60%），而根据是否存在代谢危险因素，非肥胖人群中 NAFLD 的患病率差异很大。 PNPLA3G 变体（OR=1.33，95% C.I.=1.01-1.8；P
Background & AimsThe worldwide spread of obesity is leading to a dramatic increase in the prevalence of nonalcoholic fatty liver disease (NAFLD) and its complications. We aimed to evaluate both prevalence and factors associated with NAFLD in a general population in a Mediterranean area.MethodsResultsWe considered 890 consecutive individuals included in the community-based ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study (ISRCTN15840340). Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were measured with FibroScan. Participants were genotyped for PNPLA3 rs738409 and TM6SF2 rs58542926 variants.The prevalence of NAFLD in the cohort was 48%. NAFLD participants exhibited elevated LSM values, suggesting advanced fibrosis (6.5% of cases). Both NAFLD and advanced fibrosis were independently associated with traditional risk factors (NAFLD: age >50years, obesity, hypertension, elevated ALT and low HDL-cholesterol serum concentrations. Advanced fibrosis: IFG/diabetes, elevated ALT serum concentrations). A high prevalence (>60%) of NAFLD was found in obese people, while it varied widely in non-obese people according to the presence of metabolic risk factors. PNPLA3G variant (OR=1.33, 95% C.I.=1.01-1.8; P