In Vivo Animal Models in Preclinical Evaluation of Anti-Inflammatory Activity-A Review
In Vivo Animal Models in Preclinical Evaluation of Anti-Inflammatory Activity-A Review
复制标题
抗炎活性临床前评价的体内动物模型综述
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Gowda
中科院分区：
文献类型：
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作者：
Mitul D Patel;S. Gowda
炎症被定义为活的哺乳动物组织对由于任何试剂引起的损伤的局部反应。炎症包括两个基本过程，早期炎症反应，随后是愈合。有两种类型的炎症，急性和慢性。急性炎症持续时间短，是早期的身体反应，消退迅速，通常随后愈合。慢性炎症是指组织破坏和炎症同时发生的长期过程。新物质的抗炎活性可通过多种临床前筛选方法进行评价。在此，通过使用各种致炎剂如角叉菜胶、啤酒花、葡聚糖、卵清蛋白、高岭土、气溶胶、巴豆油、棉絮来诱导炎症，并测量其诱导特性的降低量。
Inflammation is defined as the local response of li ving mammalian tissues to injury due to any agent. Inflammation involves 2 basic processes early infla mmatory response later followed by healing. There a re two types of inflammation, Acute and Chronic. Acute inf lammation is of short duration and represents the e arly body reaction, resolves quickly and is usually foll owed by healing. Chronic inflammation is defined as prolonged process in which tissue destruction and i nflammation occur at same time. The anti-inflammato ry activity of new substances can be evaluated by usin g various pre clinical screening method. Here by us e of various phlogestic agent like carragenan, brewer's y a t, dextran, egg albumin, kaolin, aerosil, croto n oil, cotton wool inflammation is induced and the amount of decr ease in its inducing characteristics is measured.