ACCUMULATED ALLELIC LOSSES IN THE DEVELOPMENT OF INVASIVE UROTHELIAL CANCER
ACCUMULATED ALLELIC LOSSES IN THE DEVELOPMENT OF INVASIVE UROTHELIAL CANCER
复制标题
DOI：
10.1002/ijc.2910530409
复制
发表时间：
1993-02-20
影响因子：
6.4
通讯作者：
YOSHIDA, O
中科院分区：
文献类型：
--
作者：
HABUCHI, T;OGAWA, O;YOSHIDA, O
为了研究等位基因丢失在尿路上皮癌发展中的作用，对 49 例不同级别和阶段的尿路上皮癌病例的 7 个染色体臂进行了杂合性丢失检查。等位基因上发现杂合性丢失的频率如下：9q (21/38, 55%)、11p (20/44, 45%)、17p (18/42,43%)、13q (10/39, 26%)、3p (8/41, 20%)、10q (2/29, 7%) 和IP（1/36，3%）。侵袭性（高级别或大于或等于 pT2）肿瘤显示 17p 丢失（1 3/16，8 1 %）和 13q 丢失（7/16，44%），其频率显着高于非侵袭性（1-2 级小于或等于顶部 TI）肿瘤。尽管 3p 缺失和 11p 缺失也更频繁地与侵袭性表型相关，但在相当数量（26 个中的 9 个，35%）非侵袭性肿瘤中检测到 11p 缺失。我们的结果表明，11p 的缺失通常可能发生在肿瘤进展中 3p、13q 或 17p 缺失之前的早期阶段。由于没有发现 9q 缺失与肿瘤分级或分期之间存在相关性，因此这种遗传改变似乎与侵袭性无关，并且可能是肿瘤发生的初始事件之一。尽管3p、11p、13q和17p等位基因的累积丢失被认为与侵袭性尿路上皮癌的发展有关，但这些多重遗传改变可能已经发生在一些病理学非侵袭性尿路上皮癌中。此外，累积等位基因丢失的模式似乎存在一些变化。
To investigate the roles of allelic loss in the development of urothelial cancer, loss of heterozygosity was examined on 7 chromosomal arms in 49 cases of urothelial cancer of various grades and stages. Loss of heterozygosity was found on alleles in order of frequency as follows: 9q (21/38, 55%), 11p (20/44, 45%), 17p (18/42,43%),13q (10/39, 26%), 3p (8/41, 20%), 10q (2/29, 7%) and Ip (1/36, 3%). Invasive (high-grade or greater-than-or-equal-to pT2) tumors showed the loss of 17p (1 3/16, 8 1 %) and the loss of 13q (7/16, 44%) with significantly higher frequencies than noninvasive (grade 1-2 less-than-or-equal-top TI) tumors. Although the loss of 3p and the loss of 11p were also more frequently associated with the invasive phenotypes, the loss of 11p was detected in a considerable number (9 of 26, 35%) of non-invasive tumors. Our results indicate that the loss of 11p might generally occur at an earlier stage before the loss of 3p, 13q or 17p in tumor progression. Since no correlation was found between the loss of 9q and the tumor grade or stage, this genetic alteration appears to be unrelated to invasiveness, and could be one of the initial events in tumorigenesis. Although accumulated allelic losses of 3p, 11p, 13q and 17p are considered to be involved in the development of the invasive type of urothelial cancers, these multiple genetic alterations may have already occurred in some pathologically non-invasive urothelial cancers. Furthermore, there appears to be some variation in the pattern of cumulative allelic loss.