Effectiveness of HIV risk reduction interventions among men who have sex with men in China: a systematic review and meta-analysis.
Effectiveness of HIV risk reduction interventions among men who have sex with men in China: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0072747
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yin L
中科院分区：
文献类型：
--
作者：
Lu H;Liu Y;Dahiya K;Qian HZ;Fan W;Zhang L;Ma J;Ruan Y;Shao Y;Vermund SH;Yin L
[目的]评价降低风险干预对中国地区男男性接触者艾滋病知识、态度和行为的影响。我们对中国男男性接触者HIV风险降低干预研究进行了系统回顾和荟萃分析。两个研究组之间或干预前后评估的标准化均数差异的汇总差值被定义为效应大小(ES)；在随机效应模型中使用标准荟萃分析来计算ES。34项符合条件的研究纳入分析，包括2项随机临床试验(RCT)、6项准实验研究、6项干预前后研究和20项系列横断面干预研究。这些研究表明，与任何男性性伴侣(平均ES，0.46；95%可信区间[CI]，0.35-0.56)、与常规性伴侣(平均ES，0.41；95%CI，0.18-0.63)和临时性伴侣(平均ES，0.52；95%CI，0.24-0.79)一致使用安全套的人数增加。对10项衡量艾滋病毒检测对感染的影响的研究的分析也显示出积极的结果(平均ES，0.55；95%CI，0.38-0.71)。降低风险干预也提高了艾滋病相关知识(均值ES，0.77；95%CI，0.60~0.94)和态度(均值ES，1.35；95%CI，0.91~1.79)，但并未降低HIV(均值ES，0.23；95%CI，0.02~0.45)和梅毒感染(均值ES，−0.01；95%CI，−0.19~0.17)。这些研究之间存在显著的异质性。总体而言，降低HIV风险干预有效地减少了中国男男性接触者的危险行为，提高了他们的知识和态度，但与HIV和梅毒流行率的变化无关。未来的研究应该使用发病率作为最终的研究结果。
To evaluate the effect of risk reduction interventions on HIV knowledge, attitudes and behaviors among men who have sex with men (MSM) in China. We performed a systematic review and meta-analysis of HIV risk reduction intervention studies among Chinese MSM. The summary difference of standardized mean differences (SMD) between both study arms or between pre- and post-intervention assessments were defined as the effect size (ES); ES was calculated using standard meta-analysis in random effects models. Thirty-four eligible studies were included in the analysis, including two randomized clinical trials (RCT), six quasi-experimental studies, six pre-and-post intervention studies, and twenty serial cross-sectional intervention studies. These studies showed an increase in consistent condom use with any male sexual partners (mean ES, 0.46; 95% confidence interval [CI], 0.35–0.56), with regular sexual partners (mean ES, 0.41; 95% CI, 0.18–0.63), and casual sexual partners (mean ES, 0.52; 95% CI, 0.24–0.79). The analysis of ten studies that measured the impact on uptake of HIV testing also showed a positive result (mean ES, 0.55; 95% CI, 0.38–0.71). The risk reduction interventions also improved HIV/AIDS-related knowledge (mean ES, 0.77; 95% CI, 0.60–0.94) and attitudes (mean ES, 1.35; 95% CI, 0.91–1.79), but did not reduce prevalence of HIV (mean ES, 0.23; 95% CI, 0.02–0.45) and syphilis infections (mean ES, −0.01; 95% CI, −0.19–0.17). There was significant heterogeneity among these studies. On aggregate, HIV risk reduction interventions were effective in reducing risky behaviors and improving knowledge and attitudes among Chinese MSM, but were not associated with a change in the prevalence of HIV and syphilis. Future studies should use incidence as definitive study outcome.
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影响因子：
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