Plasticity of the sympathetic nervous system innervating the cerebral arteries in rats
Plasticity of the sympathetic nervous system innervating the cerebral arteries in rats
复制标题
支配大鼠脑动脉的交感神经系统的可塑性
DOI：
10.1016/0014-4886(92)90190-2
复制
发表时间：
1992
影响因子：
5.3
通讯作者：
I. Nagatsu
中科院分区：
文献类型：
--
作者：
Y. Handa;Y. Nojyo;H. Ishiguro;I. Nagatsu
为探讨支配脑血管的周围交感神经系统的神经可塑性，我们观察并追踪了幼年大鼠（4周龄）单侧颈上神经节切除和/或对侧颈上神经节去中心化后，起源于对侧颈上神经节（SCG）的萌芽神经纤维进入失神经支配的脑动脉。这些神经纤维用麦胚凝集素-辣根过氧化物酶顺行标记或用抗酪氨酸羟化酶抗体化学染色。右SCG切除后8周，起源于对侧神经节的神经纤维的再支配仅在神经节切除侧的Willis环的主要脑动脉壁上形成神经丛的环形图案。然而，分散的对侧SCG，这是同时进行的单方面SCG切除，防止神经发芽到失神经支配的地区。单侧去中心化SCG本身并不影响其分布模式或其神经纤维的密度起源于神经节。它的结论是，在年轻的大鼠的交感神经纤维的生长到失神经支配的脑动脉的强烈阻碍了神经节细胞从中枢神经系统的断开，而分散单独不能影响已经建立在脑动脉系统的节后纤维的神经支配模式。
In order to investigate the neuroplasticity of the peripheral sympathetic nervous system innervating the cerebral blood vessels, we observed and traced the sprouting nerve fibers originating in the contralateral superior cervical ganglion (SCG) into the previously denervated cerebral arteries following unilateral excision of the SCG and/or decentralization of the contralateral SCG in young rats (4 weeks old). These nerve fibers were labeled anterogradely with wheat germ aggulutinin-horseradish peroxidase or stained immunohistochemically with anti-tyrosine hydroxylase antibody. Eight weeks after the right SCG excision, reinnervating nerve fibers originating in the contralateral ganglion formed a circular pattern of nerve plexus only on the wall of the main cerebral arteries of the circle of Willis in the ganglionectomized side. However, the decentralization of the contralateral SCG, which was performed simultaneously with a unilateral SCG excision, prevented the nerve sprouting into the denervated regions. Unilateral decentralization of SCG itself failed to affect their distribution pattern or their density of nerve fibers originating in the ganglion. It is concluded that in the young rat the outgrowth of the sympathetic nerve fibers into the denervated cerebral arteries was strongly impeded by the disconnection of ganglion cells from the central nervous system, while the decentralization alone could not affect the innervation pattern of the postganglionic fibers which have been already built-up in the cerebral arterial system.