Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses
Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses
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DOI：
10.1016/j.humimm.2009.11.002
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发表时间：
2010-02-01
期刊：
影响因子：
2.7
通讯作者：
Poland, Gregory A.
中科院分区：
文献类型：
--
作者：
Kennedy, Richard B.;Ovsyannikova, Inna G.;Poland, Gregory A.
人类白细胞抗原（HLA）基因在宿主免疫，包括疫苗应答中起着关键作用。HLA分子向T细胞呈递抗原肽并向NK细胞提供抑制信号，HLA基因内的多态性允许结合和呈递多种多样的自身和外源肽。已发现HLA等位基因的杂合性在多种感染的宿主防御中起积极作用。一个或多个HLA基因座内的纯合性可能限制该表位库并限制T细胞对感染或疫苗接种的应答。在这里，我们报告说，HLA DPB 1基因座内的纯合性与风疹特异性IgG水平的增加有关，这种效应是由一个共同的等位基因DPB 1 *0401驱动的。我们还表明，不同的HLA I类和II类基因座内的纯合性与风疹病毒刺激后白细胞介素（IL）-2，IL-5和IL-10分泌的变化（但不一定减少）相关。(C)2010年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.