Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions
Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions
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DOI：
10.1039/c7re00193b
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发表时间：
2018-02-01
影响因子：
3.9
通讯作者：
Booker-Milburn, K. I.
中科院分区：
文献类型：
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作者：
Elliott, L. D.;Knowles, J. P.;Booker-Milburn, K. I.
人们认为光化学放大的困难是阻碍其广泛使用的主要障碍之一。在这里，我们采取了三种不同的具有挑战性的反应，并表明它们可以可靠地扩大规模，从浸没井间歇反应器到更高功率的FEP流动反应器。成功的关键是开发了一种强大的计算方法，使从这些和以前优化的间歇反应中准确计算反应器流量成为可能。尽管这些系统具有挑战性，但在所有情况下都获得了数十克的材料。
The perceived difficulty of the scale-up of photochemistry is one of the main obstacles preventing its widespread use. Herein, we take three different challenging reactions and show that they can be reliably scaled, from immersion well batch reactors to higher power FEP flow reactors. Key to the success has been the development of a powerful calculation methodology which enables the accurate calculation of reactor flow rates from these and previously optimised batch reactions. Despite the challenging nature of these systems, in all cases tens of grams of material was obtained.