SNX9-a prelude to vesicle release
SNX9-a prelude to vesicle release
复制标题
DOI：
10.1242/jcs.037135
复制
发表时间：
2009-01-01
影响因子：
4
通讯作者：
Carlsson, Sven R.
中科院分区：
文献类型：
--
作者：
Lundmark, Richard;Carlsson, Sven R.
在过去的几年中，分类连接蛋白SNX 9被挑选出来作为参与基本细胞活动的重要蛋白质。SNX 9与发动蛋白强烈结合，并部分负责将这种GT3募集到内吞作用位点。SNX 9还具有高的调节膜的能力，因此可能在发生断裂之前参与内吞囊泡的窄颈的形成。一旦组装在膜上，SNX 9刺激发动蛋白的GT3活性以促进断裂反应。也已经清楚的是，SNX 9具有以膜依赖性方式激活肌动蛋白调节剂N-WASP以协调肌动蛋白聚合与囊泡释放的能力。在这篇评论中，我们总结了SNX 9在膜重塑背景下的结构和功能的几个方面，讨论了它与各种相互作用伙伴的相互作用，并提出了SNX 9如何在胞吞作用中发挥作用的模型。
The sorting nexin SNX9 has, in the past few years, been singled out as an important protein that participates in fundamental cellular activities. SNX9 binds strongly to dynamin and is partly responsible for the recruitment of this GTPase to sites of endocytosis. SNX9 also has a high capacity for modulation of the membrane and might therefore participate in the formation of the narrow neck of endocytic vesicles before scission occurs. Once assembled on the membrane, SNX9 stimulates the GTPase activity of dynamin to facilitate the scission reaction. It has also become clear that SNX9 has the ability to activate the actin regulator N-WASP in a membrane-dependent manner to coordinate actin polymerization with vesicle release. In this Commentary, we summarize several aspects of SNX9 structure and function in the context of membrane remodeling, discuss its interplay with various interaction partners and present a model of how SNX9 might work in endocytosis.