Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia
Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia
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DOI：
10.4161/cbt.7.2.5262
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发表时间：
2008-02-01
影响因子：
3.6
通讯作者：
McMillan, Nigel A. J.
中科院分区：
文献类型：
--
作者：
Chen, Jiezhong;McMillan, Nigel A. J.
B细胞慢性淋巴细胞白血病（CLL）是由外周血和骨髓中非功能性B细胞的异常积聚引起的。然而，该病的确切病因和机制尚不清楚。最近，在识别可能导致CLL的遗传缺陷和环境因素方面取得了进展。这为疾病的性质提供了一些线索，但没有确定的治疗方法。虽然治疗增加了缓解时间，但目前这种疾病无法通过常规治疗治愈。CLL的发病机制需要进一步研究，因为是合适的细胞系和动物模型的发展，在其中研究it.This审查总结了CLL的最新进展，重点是分子事件和可能的影响，在治疗。
B-cell chronic lymphocytic leukemia (CLL) is caused by the abnormal accumulation of non-functional B-cells in peripheral blood and bone marrow. However, the precise aetiology and mechanism of the disease are unclear. Recently, progress has been made in the identification of both the genetic deficiencies and environmental factors that may underlie CLL. This has provided some clues to the nature of the disease, but no definitive cures. Although treatment has increased remission time, at present the disease is not curable by conventional therapy. Further studies of the pathogenesis of CLL are needed, as are the development of suitable cell lines and animal models in which to study it. This review summarises the most recent progress in CLL with emphasis on molecular events and possible implications in therapy.