Synthesis of N‐Arylamides by Copper‐Catalyzed Amination of Aryl Halides with Nitriles
Synthesis of N‐Arylamides by Copper‐Catalyzed Amination of Aryl Halides with Nitriles
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DOI：
10.1002/adsc.201300189
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发表时间：
2013-05
影响因子：
5.4
通讯作者：
Shi-Kai Xiang;Dongxue Zhang;Haoxiang Hu;Jiang-Ling Shi;L. Liao;C. Feng;Bi-qin Wang;K. Zhao;
中科院分区：
文献类型：
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作者：
Shi-Kai Xiang;Dongxue Zhang;Haoxiang Hu;Jiang-Ling Shi;L. Liao;C. Feng;Bi-qin Wang;K. Zhao;
发展了一种铜催化的卤代芳烃与腈的胺化反应。用腈类作氮亲核试剂，可使N-芳基酰胺的合成比酰胺原位水解法简单。根据该方法可以合成多种N-芳基酰胺和苯并恶唑衍生物。
A copper-catalyzed amination of aryl halides with nitriles has been developed. The use of nitriles as nitrogen nucleophiles can make the synthesis of N-arylamides more simple than that using amides through in-situ hydrolysis. A variety of N-arylamides and benzoxazole derivatives can be synthesized according to this approach.