Gastric emptying in Parkinson's disease: Patients with and without response fluctuations
Gastric emptying in Parkinson's disease: Patients with and without response fluctuations
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DOI：
10.1212/wnl.46.4.1051
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发表时间：
1996-04-01
期刊：
影响因子：
9.9
通讯作者：
Melamed, E
中科院分区：
文献类型：
--
作者：
Djaldetti, R;Baron, J;Melamed, E
胃排空延迟可能是一个重要的药代动力学机制，潜在的一些反应波动后，长期左旋多巴治疗。我们进行了放射性核素胃排空研究，使用标准的Tc-99 m胶体标记的固体餐在30例帕金森病（PD），15波动与“延迟”和“无”的现象，和15 nonvolatile。给予禁食患者标准餐，并使用放置在胃上的伽马照相机监测胃排空，记录1小时的数据。与正常对照受试者相比，PD患者在60分钟后测量胃排空延长（70.7 +/- 16% vs < 60%）。与无波动的患者相比，波动患者1小时后测量的胃潴留增加（77.4 +/- 15.5% vs 64.0 +/- 14.3%; p < 0.05）。半ti;与无反应波动的患者相比，有反应波动的患者NE排空显著延迟（221 ± 202分钟对85 ± 31分钟; P < 0.05）。这表明胃排空延迟在PD患者中很常见，并且在反应波动的患者中更为明显。胃是PD的重要靶器官，受到基本PD病理学、长期药物给药或两者的影响。
Delayed gastric emptying may be an important pharmacokinetic mechanism underlying some of the response fluctuations that develop after long-term levodopa therapy. We performed a radionuclide gastric emptying study using a standard Tc-99m colloid-labeled solid meal in 30 patients with Parkinson's disease (PD), 15 fluctuators with ''delayed-on'' and ''no-on'' phenomena, and 15 nonfluctuators. Fasting patients were given the standard meal, and gastric emptying was monitored with a gamma camera positioned over the stomach, recording data for 1 hour. PD patients had prolonged gastric emptying measured after 60 minutes compared with the normal control subjects (70.7 +/- 16% versus < 60%). Gastric retention measured after 1 hour was increased in patients with fluctuations compared with patients without fluctuations (77.4 +/- 15.5% versus 64.0 +/- 14.3%; p < 0.05). Half-ti;ne emptying was significantly delayed in patients with, as compared with those without, response fluctuations (221 +/- 202 minutes versus 85 +/- 31 minutes; p < 0.05). This demonstrates that delayed gastric emptying is common in PD patients and is more marked in those with response fluctuations. The stomach is an important target organ in PD, affected either by the basic PD pathology, chronic drug administration, or both.