Deficits in Action Selection Based on Numerical Information After Inactivation of the Posterior Parietal Cortex in Monkeys
Deficits in Action Selection Based on Numerical Information After Inactivation of the Posterior Parietal Cortex in Monkeys
复制标题
DOI：
10.1152/jn.01014.2009
复制
发表时间：
2010-08-01
影响因子：
2.5
通讯作者：
Tanji, Jun
中科院分区：
文献类型：
--
作者：
Sawamura, Hiromasa;Shima, Keisetsu;Tanji, Jun
张建军，张建军，张建军，等。脑后顶叶皮层失活后的动作选择缺陷。中国生物医学工程学报（英文版），2009,31(4):591 - 591。首次发表于2010年5月26日；doi: 10.1152 / jn.01014.2009。先前的一项研究发现，猴子后顶叶皮层5区的神经元活动反映了一系列自我行为的数量。然而，目前尚不清楚的是，第5区是否在基于数字信息的行动选择中发挥了关键作用，还是仅仅反映了源自大脑其他区域的与数字相关的信号。我们暂时和局部灭活了5区，以测试其功能对基于数字的动作选择的贡献。两只猴子接受训练，根据视觉触发信号推或转动手柄。动作的选择完全基于猴子执行的一系列动作的数字信息：选择a五次，选择B五次，然后以循环的方式返回a。当将muscimol应用于记录数量选择细胞活动的区域5时，选择任务的错误率显着增加。这种短暂的神经失活也引起了在注射muscimol之前没有观察到的遗漏错误。一项控制任务表明，这些错误不是由运动缺陷或在两种可能的动作之间进行选择的能力受损引起的。我们的结果表明，区域5对于根据被测试个体执行的一系列动作的数字信息选择动作至关重要。
Sawamura H, Shima K, Tanji J. Deficits in action selection based on numerical information after inactivation of the posterior parietal cortex in monkeys. J Neurophysiol 104: 902-910, 2010. First published May 26, 2010; doi: 10.1152/jn.01014.2009. A previous study identified neuronal activity in area 5 of the monkey posterior parietal cortex that reflects the numerosity of a series of self-performed actions. It is not known, however, whether area 5 is crucially involved in the selection of an action based on numerical information or, instead, merely reflects numerosity-related signals that originate in other brain regions. We transiently and focally inactivated area 5 to test its functional contributions to numerosity-based action selection. Two monkeys were trained to either push or turn a handle in response to a visual trigger signal. The selection of the action was solely based on numerical information from a series of actions performed by the monkey: select A five times, select B five times, and then return to A in a cyclical fashion. When muscimol was applied to a portion of area 5 in which the activity in the numerosity-selective cells was recorded, the error rate in the selection task increased significantly. This transient neural inactivation also caused omission errors that were not observed before the muscimol injection. A control task showed that the errors were not caused by motor deficits or impaired ability to select between two possible actions. Our results indicate that area 5 is crucial for selecting actions on the basis of numerical information about a series of actions performed by the tested individual.