White Matter Integrity Dissociates Verbal Memory and Auditory Attention Span in Emerging Adults with Congenital Heart Disease
White Matter Integrity Dissociates Verbal Memory and Auditory Attention Span in Emerging Adults with Congenital Heart Disease
复制标题
DOI：
10.1017/s135561771400109x
复制
发表时间：
2015-01-01
影响因子：
2.6
通讯作者：
Mahle, William T.
中科院分区：
文献类型：
--
作者：
Brewster, Ryan C.;King, Tricia Z.;Mahle, William T.
白色物质中断已被确定在个人与先天性心脏病（CHD）。然而，没有具体的理论驱动的微结构白色物质中断和认知之间的关系已经建立在冠心病。我们进行了两部分研究。首先，我们确定了显着差异分数各向异性（FA）的新兴成人冠心病使用基于道的空间统计（TBSS）。对22名CHD患者和18名人口统计学上相似的对照者进行TBSS分析，发现CHD患者中有5个区域的白色物质正常，FA显著较低，2个较高。接下来，选择CHD中FA较低的两个区域来研究理论驱动的与认知的差异关系：沿着左侧钩束的体素（UF;理论上有助于言语记忆的束）和沿着右侧小脑中脚的体素（MCP;以前与注意力有关的束）。在CHD中，发现UF FA与记忆力之间存在显著正相关，r（20）= .42，p = .049（未校正）。UF与听觉注意广度无相关性。发现MCP FA与听觉注意广度之间呈正相关，r（20）= .47，p = .027（未校正）。MCP与记忆无相关性。在对照组中，未发现显著关系。这些结果与先前的文献一致，证明年轻CHD样本中FA较低，并为新发CHD成人中白色完整性破坏提供了新证据。此外，一个相关的双重分离建立了不同的白色物质电路（UF和MCP）和差异的认知相关（记忆和注意广度，分别）在年轻的成年人与CHD。
White matter disruptions have been identified in individuals with congenital heart disease (CHD). However, no specific theory-driven relationships between microstructural white matter disruptions and cognition have been established in CHD. We conducted a two-part study. First, we identified significant differences in fractional anisotropy (FA) of emerging adults with CHD using Tract-Based Spatial Statistics (TBSS). TBSS analyses between 22 participants with CHD and 18 demographically similar controls identified five regions of normal appearing white matter with significantly lower FA in CHD, and two higher. Next, two regions of lower FA in CHD were selected to examine theory-driven differential relationships with cognition: voxels along the left uncinate fasciculus (UF; a tract theorized to contribute to verbal memory) and voxels along the right middle cerebellar peduncle (MCP; a tract previously linked to attention). In CHD, a significant positive correlation between UF FA and memory was found, r(20) = .42, p = .049 (uncorrected). There was no correlation between UF and auditory attention span. A positive correlation between MCP FA and auditory attention span was found, r(20) = .47, p = .027 (uncorrected). There was no correlation between MCP and memory. In controls, no significant relationships were identified. These results are consistent with previous literature demonstrating lower FA in younger CHD samples, and provide novel evidence for disrupted white matter integrity in emerging adults with CHD. Furthermore, a correlational double dissociation established distinct white matter circuitry (UF and MCP) and differential cognitive correlates (memory and attention span, respectively) in young adults with CHD.