Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes
Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes
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DOI：
10.1093/molbev/msg084
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发表时间：
2003-05-01
影响因子：
10.7
通讯作者：
Durrett, R
中科院分区：
文献类型：
--
作者：
Calabrese, P;Durrett, R
我们使用最大似然估计方法对几个微卫星突变模型进行拟合，以获得果蝇和人类基因组中二核生物重复序列的长度分布。所有简单的模型都会被此过程拒绝。两个新的模型，一个是二次模型，另一个是分段线性滑移率模型，通过预测长的微卫星偏向收缩，得到了最好的拟合，并与最近的实验研究相一致。
We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.