CHANGES IN SERUM ENZYME LEVELS ACCOMPANYING CARDIAC SURGERY WITH EXTRACORPOREAL CIRCULATION
CHANGES IN SERUM ENZYME LEVELS ACCOMPANYING CARDIAC SURGERY WITH EXTRACORPOREAL CIRCULATION
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DOI：
10.1136/jcp.19.3.220
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发表时间：
1966-01-01
影响因子：
3.4
通讯作者：
MOSS, DW
中科院分区：
文献类型：
--
作者：
WELBOURN, N;MELROSE, DG;MOSS, DW
术后 2 周，每天测量 22 名接受体外循环心脏手术患者血清中的乳酸脱氢酶、α-羟基丁酸脱氢酶、异柠檬酸脱氢酶和谷草酰乙酸转氨酶活性，持续两周。研究发现灌注时间是影响术后酶活性增加程度的主要因素。与灌注不足 1 小时的患者相比，灌注超过 1 小时的患者的水平显着更高。肝细胞损伤、年龄和手术类型不被认为是决定这种活性增加程度的主要因素。当考虑到通过将患者的循环与心肺机的预充液混合而引入的稀释时，发现在灌注期间发生酶活性的显着增加。考虑到这种稀释，观察到的酶活性增加了 30% 至 50%。
Serum lactric dehydrogenase, alpha-hydroxy-butyrate dehydrogenase, iso-citric dehydrogenase, and glutamic oxaloacetic transaminase activities were measured daily for 2 weeks postoperatively in the serum of 22 patients undergoing cardiac surgery with extracorporeal circulation. The length of perfusion was found to be a major factor affecting the extent of increased postoperative enzyme activities. Significantly higher levels were demonstrated in patients perfused for over 1 hour compared with those perfused for under 1 hour. Hepatocellular damage, age, and type of operation were not considered to be major factors in determining the extent of this increased activity. A considerable increase in enzyme activity was found to occur during perfusion when the dilution introduced by mixing the patient''s circulation with the priming fluid of the heart-lung machine was taken into account. This dilution, when accounted for, increased the observed enzyme activity by 30 to 50%.