APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
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April是肿瘤坏死因子家族的新配体，刺激肿瘤细胞生长。
DOI：
10.1084/jem.188.6.1185
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发表时间：
1998-09-21
影响因子：
15.3
通讯作者：
Tschopp, J
中科院分区：
文献类型：
--
作者：
Hahne, M;Kataoka, T;Schroter, M;Hofmann, K;Irmler, M;Bodmer, J L;Schneider, P;Bornand, T;Holler, N;French, L E;Sordat, B;Rimoldi, D;Tschopp, J
肿瘤坏死因子（TNF）家族的成员诱导多效性生物反应，包括细胞生长、分化，甚至死亡。在这里，我们描述了一个新的成员的TNF家族指定APRIL（增殖诱导配体）。虽然APRIL的转录物在正常组织中丰度低，但在转化细胞系以及体内结肠癌、甲状腺癌和淋巴组织中检测到高水平的mRNA。将重组APRIL添加到各种肿瘤细胞中刺激其增殖。此外，与亲本细胞系相比，APRIL转染的NIH-3 T3细胞在裸鼠中显示出增加的肿瘤生长速率。这些发现表明，APRIL可能参与肿瘤细胞生长的调节。
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.