Innervation of scar tissue in the skin of the rat.
Innervation of scar tissue in the skin of the rat.
复制标题
大鼠皮肤疤痕组织的神经支配。
DOI：
10.3109/02844317809012992
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
T. Waris
中科院分区：
文献类型：
--
作者：
T. Waris
在这项研究中，用组织化学方法研究了瘢痕组织的再神经支配，以显示儿茶酚胺荧光和非特异性胆碱酯酶活性。疤痕是由大鼠背部皮肤缺陷的愈合和收缩造成的。术后4周在瘢痕处可见第一批显示非特异性胆碱酯酶活性的再生神经。在整个研究期间，也就是手术后20周，在瘢痕中只发现了自由再生的神经，没有观察到被包裹的神经末梢。瘢痕组织致密的胶原区未见荧光肾上腺素能神经。然而，在瘢痕下疏松的再生结缔组织中观察到再生的荧光神经。这些神经中的大多数都跟随血管的走向。在本工作中，观察到瘢痕组织的强烈收缩，并观察到瘢痕组织与游离神经的神经支配较差。这些再生神经末梢在感觉辨别中的作用，以及不同的递质在感觉系统中作用的重要性进行了讨论。
In this study the reinnervation of scar tissue was investigated histochemically to demonstrate catecholamine fluorescence and nonspecific cholinesterase activity. The scarring was produced by healing and contraction of a defect in the dorsal skin of the rat. The first regenerating nerves showing nonspecific cholinesterase activity were observed in the scar four weeks postoperatively. Throughout the investigation period, that is up to twenty weeks after the operation, only free regenerated nerves were found in the scar; no encapsulated nerve endings were observed. No fluorescent adrenergic nerves were found in the dense collagenous part of the scar tissue. Regenerated fluorescent nerves were, however, observed in the loose regenerated connective tissue under the scar. Most of these nerves followed the course of blood vessels. In the present work a vigorous contraction of the scar tissue was noted and a poor innervation of the scar tissue with free nerves was observed. The role of these regenerated nerve endings in sensory discrimination, and the importance of different transmitters acting in the sensory system are discussed.