Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
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微生物和微生物毒素：微生物-粘膜相互作用的范例。
DOI：
10.1152/ajpgi.2001.280.6.g1049
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Reed,SL
中科院分区：
文献类型：
--
作者：
StanleyJr,SL;Reed,SL
G1049-G1054, 2001年。原生动物肠道寄生虫溶组织内阿米巴仍然是世界范围内发病率和死亡率的重要原因。溶组织肠杆菌引起两种主要的临床症状，阿米巴结肠炎和阿米巴肝脓肿。体外和体内疾病模型的发展、新的遗传方法、关键溶组织芽胞杆菌毒力因子的鉴定以及宿主对感染反应的关键因素的识别等方面的最新进展，使人们对阿米巴感染的发病机制有了重要的了解。溶组织芽胞杆菌的毒力因子包括1)一种表面半乳糖结合凝集素，它介导溶组织芽胞杆菌与宿主细胞的结合，并可能促进阿米巴对补体的抗性；2)阿米巴孔，一种能够裂解细胞的小肽，可能在杀死肠上皮细胞、肝细胞和宿主防御细胞中起作用；3)一种分泌半胱氨酸蛋白酶家族，在溶组织芽胞杆菌组织入侵、逃避宿主防御中起关键作用。寄生虫诱导肠道炎症。变形虫既能裂解宿主细胞，又能通过程序性细胞死亡诱导宿主细胞自杀。宿主反应也是影响感染结果的一个重要因素，中性粒细胞可能在阿米巴病的组织损伤和控制阿米巴感染中发挥关键作用。阿米巴病;阿米巴的发病机理
G1049–G1054, 2001.—The protozoan intestinal parasite Entamoeba histolytica remains a significant cause of morbidity and mortality worldwide. E. histolytica causes two major clinical syndromes, amebic colitis and amebic liver abscess. Recent advances in the development of in vitro and in vivo models of disease, new genetic approaches, the identification of key E. histolytica virulence factors, and the recognition of crucial elements of the host response to infection have led to significant insights into the pathogenesis of amebic infection. E. histolytica virulence factors include 1) a surface galactose binding lectin that mediates E. histolytica binding to host cells and may contribute to amebic resistance to complement, 2) amebapores, small peptides capable of lysing cells, which may play a role in killing intestinal epithelial cells, hepatocytes, and host defense cells, and 3) a family of secreted cysteine proteinases that play a key role in E. histolytica tissue invasion, evasion of host defenses, and parasite induction of gut inflammation. Amebae can both lyse host cells and induce their suicide through programmed cell death. The host response is also an important factor in the outcome of infection, and neutrophils may play a key role in contributing to the tissue damage seen in amebiasis and in controlling amebic infection. amebiasis; amebic pathogenesis