Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
复制标题
DOI：
10.1038/s41592-019-0459-y
复制
发表时间：
2019-07-01
期刊：
影响因子：
48
通讯作者：
Rand, Kasper D.
中科院分区：
文献类型：
--
作者：
Masson, Glenn R.;Burke, John E.;Rand, Kasper D.
氢氘交换质谱（HDX-MS）是一种功能强大的生物物理技术，越来越多地应用于各种各样的问题。随着HDX-MS社区的不断发展，在数据收集、分析、呈现和解释方面采用最佳实践将大大提高非专业人士对这项技术的可访问性。在这里，我们提供了来自第一届国际氢交换质谱会议（IC-HDX; 2017）的社区讨论的建议。它的目的是代表一个共识的观点和一个机会，以刺激进一步的补充和完善，随着该领域的进步。
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.