Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans.
Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans.
复制标题
白色念珠菌芽和菌丝体形成过程中细胞壁扩张的时间和空间差异。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
D. Soll
中科院分区：
文献类型：
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作者：
M. Staebell;D. Soll
传染性酵母菌白色念珠菌能够以出芽或菌丝体的形式生长，这取决于支持介质的pH值。通过监测牢牢附着在生长细胞壁上的聚赖氨酸包被珠的位置，细胞壁表面的膨胀区已被绘制为替代生长形式。空间和时间差异都被证明是存在的。在芽生长的前三分之二，一个非常小的，高度活跃的顶端区约占表面扩张的70%。剩下的30%是由于总体扩张。当芽达到其最终表面积的大约三分之二时，顶端区域关闭，随后的扩张由一般机制完成。在菌丝生长过程中，至少90%的扩张是由于一个小的、高度活跃的顶端生长区，不到10%是由于一般机制。与出芽细胞不同的是，只要以菌丝的形式继续生长，生长中的菌丝的顶端区就不会关闭。这些不同的时间和空间差异的扩张被认为是在假丝酵母的调节替代表型。
The infectious yeast Candida albicans is capable of growing in either a budding or mycelium form, depending upon the pH of the supporting medium. By monitoring the position of polylysine-coated beads firmly attached to the wall of growing cells, the zones of expansion for the surface of the cell wall have been mapped for the alternative growth forms. Both spatial and temporal differences are demonstrated to exist. During roughly the first two-thirds of bud growth, a very small, highly active apical zone accounts for roughly 70% of surface expansion. The remaining 30% is due to general expansion. When a bud reaches approximately two-thirds of its final surface area, the apical zone shuts down, and subsequent expansion is completed by the general mechanism. During mycelial growth, at least 90% of expansion is due to a small, highly active apical growth zone, and less than 10% is due to the general mechanism. In contrast to budding cells, the apical zone of the growing mycelium never shuts down as long as growth continues in the mycelial form. These distinct temporal and spatial differences in expansion are considered in terms of the regulation of alternative phenotypes in Candida.