Phyteumosides A and B: New Saponins with Unique Triterpenoid Aglycons from Phyteuma orbiculare L.
Phyteumosides A and B: New Saponins with Unique Triterpenoid Aglycons from Phyteuma orbiculare L.
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DOI：
10.1021/ol200047v
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发表时间：
2011-03-18
期刊：
影响因子：
5.2
通讯作者：
Potterat, Olivier
中科院分区：
文献类型：
--
作者：
Abbet, Christian;Neuburger, Markus;Potterat, Olivier
从风铃科植物轮叶商陆地上部分分离得到两个三萜苷元，分别为三萜皂苷A(1)和B(2)。它们的结构经波谱和化学方法确证，并用X-射线衍射法对酶解得的苷元进行了确证。1的苷元可以被认为是一个不完全环化的螺环或伽马螺环三萜，其中有两个额外的四氢吡喃环来自氧桥。化合物2含有一个新的17-聚己烯苷元。
Phyteumosides A (1) and B (2), two saponins with unprecedented triterpenoid aglycons, were isolated from the aerial parts of Phyteuma orbiculare (Campanulaceae). Their structures were elucidated by spectroscopic and chemical methods and corroborated by X-ray diffraction analyses of the aglycons obtained through enzymatic hydrolysis. The aglycon of 1 can be considered as an incompletely cyclized onoceroid or gammaceroid triterpene with two additional tetrahydropyran rings arising from oxygen bridges. Compound 2 possesses a new 17-polypodene aglycon.