Lung CD4-CD8- Double-Negative T Cells Are Prominent Producers of IL-17A and IFN-γ during Primary Respiratory Murine Infection with Francisella tularensis Live Vaccine Strain
Lung CD4-CD8- Double-Negative T Cells Are Prominent Producers of IL-17A and IFN-γ during Primary Respiratory Murine Infection with Francisella tularensis Live Vaccine Strain
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DOI：
10.4049/jimmunol.1000362
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发表时间：
2010-05-15
影响因子：
4.4
通讯作者：
Elkins, Karen L.
中科院分区：
文献类型：
--
作者：
Cowley, Siobhan C.;Meierovics, Anda I.;Elkins, Karen L.
对于几种细胞内感染，肺部疫苗接种提供了可测量的更好的保护，防止肺部挑战。导致肺部免疫应答的独特因素尚未得到很好的表征。在这项研究中，我们表明，CD 4（-）CD 8（-）双阴性（DN）T细胞是一个主要的响应T细胞亚群在肺部的土拉弗朗西斯菌活疫苗株（LVS）感染小鼠肺。DN T细胞是次要的（
For several intracellular infections, pulmonary vaccination provides measurably better protection against pulmonary challenge. The unique factors that contribute to pulmonary immune responses are not well characterized. In this study, we show that CD4(-) CD8(-) double negative (DN) T cells are a major responding T cell subset in the lungs of mice during pulmonary Francisella tularensis live vaccine strain (LVS) infection. DN T cells were a minor (