Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.
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DOI:
10.1016/j.yjmcc.2021.04.002
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发表时间:
2021-07
影响因子:
5
通讯作者:
Terentyev D
Terentyev D
中科院分区:
医学2区
文献类型:
--
作者:
Hamilton S;Terentyeva R;Clements RT;Belevych AE;Terentyev D

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Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease. Figure created with BioRender.com.
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