Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender.
Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender.
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全球和区域左心室心肌变形测量通过磁共振特征跟踪健康志愿者：与性别的标记和相关性进行比较。
DOI：
10.1186/1532-429x-15-8
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发表时间：
2013-01-18
期刊：
影响因子：
--
通讯作者：
Leeson P
中科院分区：
文献类型：
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作者：
Augustine D;Lewandowski AJ;Lazdam M;Rai A;Francis J;Myerson S;Noble A;Becher H;Neubauer S;Petersen SE;Leeson P
功能跟踪软件提供心肌应变，速度和位移从电影心血管磁共振（CMR）图像的测量。我们用它来记录健康成年人的变形参数，并将其值与通过标记获得的值进行比较。我们使用TomTec 2D Cardiac Performance Analysis软件，在145名健康志愿者中推导出全局、区域和节段心肌变形参数，这些志愿者在1.5 T Siemens Sonata扫描仪上获得了稳态自由进动（SSFP）电影左心室短轴视图（基底、中间和心尖水平）和长轴视图（水平长轴、垂直长轴和左心室流出道）。20名受试者还进行了标记采集，我们将从这些采集中获得的全局和区域变形值与从特征跟踪中获得的值进行了比较。对于应变的全局平均测量值，只有短轴切片中的周向测量值显示FT和标记之间相当好的一致性水平（一致性限度为-0.06至0.04）。纵向应变显示出较宽的一致性范围（-0.16至0.03），有证据表明，随着两种测量方法的平均值增加，FT相对于标记法高估了应变。相对于标记，FT系统性地高估了径向应变，其一致性范围非常宽，高达平均值的100%（-0.01至0.23）。再现性显示出相似的相对趋势，周向测量的整体观察者间变异性可接受（变异系数为4.9%），但径向方向的再现性较差（变异系数为32.3%）。变形参数的范围在基底、中间和顶端LV水平之间变化，基底水平高于顶端，并且通过FT和标记在性别之间变化。周向而非纵向或径向全局应变的FT测量结果与标记结果合理一致，观察者间重现性可接受。我们在全球，区域和节段水平上记录FT变形参数的临时范围。它们显示了研究志愿者中性别和心肌区域变化的证据，但尚未与节段水平的标记测量进行比较。
Feature Tracking software offers measurements of myocardial strain, velocities and displacement from cine cardiovascular magnetic resonance (CMR) images. We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging. We used TomTec 2D Cardiac Performance Analysis software to derive global, regional and segmental myocardial deformation parameters in 145 healthy volunteers who had steady state free precession (SSFP) cine left ventricular short (basal, mid and apical levels) and long axis views (horizontal long axis, vertical long axis and left ventricular out flow tract) obtained on a 1.5 T Siemens Sonata scanner. 20 subjects also had tagged acquisitions and we compared global and regional deformation values obtained from these with those from Feature Tracking. For globally averaged measurements of strain, only those measured circumferentially in short axis slices showed reasonably good levels of agreement between FT and tagging (limits of agreement −0.06 to 0.04). Longitudinal strain showed wide limits of agreement (−0.16 to 0.03) with evidence of overestimation of strain by FT relative to tagging as the mean of both measures increased. Radial strain was systematically overestimated by FT relative to tagging with very wide limits of agreement extending to as much as 100% of the mean value (−0.01 to 0.23). Reproducibility showed similar relative trends with acceptable global inter-observer variability for circumferential measures (coefficient of variation 4.9%) but poor reproducibility in the radial direction (coefficient of variation 32.3%). Ranges for deformation parameters varied between basal, mid and apical LV levels with higher levels at base compared to apex, and between genders by both FT and tagging. FT measurements of circumferential but not longitudinally or radially directed global strain showed reasonable agreement with tagging and acceptable inter-observer reproducibility. We record provisional ranges of FT deformation parameters at global, regional and segmental levels. They show evidence of variation with gender and myocardial region in the volunteers studied, but have yet to be compared with tagging measurements at the segmental level.