Contribution of pregnancy, fetuses, fetal placentas and deciduomas to mammary gland and uterine development.
Contribution of pregnancy, fetuses, fetal placentas and deciduomas to mammary gland and uterine development.
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妊娠、胎儿、胎儿胎盘和蜕膜瘤对乳腺和子宫发育的贡献。
DOI：
10.1210/endo-83-4-907
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发表时间：
1968
期刊：
影响因子：
4.8
通讯作者：
H. Tucker
中科院分区：
文献类型：
--
作者：
C. Desjardins;M. Paape;H. Tucker
在大鼠中，研究了妊娠、胎仔、胎仔胎盘和有和无蜕膜瘤的假胎盘对乳腺和子宫发育（DNA含量）和代谢（RNA含量）的影响。乳腺核酸含量在整个妊娠期增加。在妊娠中期之前而不是之后移除胎儿会干扰乳腺DNA和RNA含量的正常增加。切除胎儿胎盘导致乳房发育倒退到非妊娠对照值。假孕前12天的乳房发育比孕12天的大鼠少29-33%。提示母体激素是妊娠前半期乳腺发育的主要刺激因子。然而，胎儿胎盘在孕中期之前就开始刺激乳房发育，并且它们可能是妊娠后半期乳房发育的主要限制因素。子宫DNA增加了2.8倍，而子宫RNA和体重分别增加了5.8倍和4.6倍。
In rats, the influence of pregnancy, fetuses, fetal placentas and pseudopregnancy with and without deciduomas on mammary and uterine development (DNA content) and metabolism (RNA content) was studied. Mammary nucleic acid content increased throughout pregnancy. Removal of fetuses before midpregnancy, but not after, interfered with normal increases in mammary DNA and RNA content. Excision of fetal placentas caused mammary development to regress to nonpregnant control values. Mammary development during the first 12 days of pseudopregnancy was 29–33% less than that observed in 12-day pregnant rats. It is suggested that maternal hormones are the primary stimulant of mammary development during the first half of pregnancy. However, the fetal placentas commence to stimulate mammary development before midpregnancy, and they may be the primary limiting factor for mammary development during the second half of pregnancy. Uterine DNA increased 2.8-fold, whereas uterine RNA and weight increased 5.8- and 4.6-fold, resp...