915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes
915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes
复制标题
基于非化学计量 Na0.52YbF3.52:Er 上转换纳米探针的 915 nm 光触发光动力治疗和 MR/CT 双模态肿瘤成像
DOI：
10.1002/smll.201601023
复制
发表时间：
2016
期刊：
影响因子：
13.3
通讯作者：
Lin Hongzhen
中科院分区：
文献类型：
--
作者：
Huang Yanan;Xiao Qingbo;Hu Huishan;Zhang Kunchi;Feng Yamin;Li Fujin;Wang Jian;Ding Xianguang;Jiang Jiang;Li Yanfang;Shi Liyi;Lin Hongzhen
稀土离子掺杂的上转换纳米粒子（UCNPs）作为新一代的多模式生物探针，在临床诊断领域引起了人们极大的兴趣。本文中，红色发射的非化学计量比的Na 0.52YbF3.52：Er UCNPs的高发光强度和色纯度的合成通过一个简单的溶剂热方法。来自本发明纳米磷光体的红色UC发射比来自尺寸为30 nm的六方相NaYF 4：Yb，Er UCNP的公知的绿色发射强三倍。通过利用Na0.52YbF3.52：Er@SrF2UCNP作为多功能纳米平台，首次实现了高效的体外和体内915 nm光触发光动力疗法，与980 nm光触发的疗法相比，过热显著减少，但治疗效果相似。此外，凭借Yb 3+离子的高横向弛豫率（r2）和强X射线衰减能力，这些UCNP还表现出作为高对比度磁共振和X射线计算机断层扫描双模成像的造影剂的良好性能。我们的研究显示了红色发射Na0.52YbF3.52：Er UCNPs用于肿瘤的多模态成像引导光动力学治疗的巨大潜力。
Lanthanide (Ln3+)‐doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52YbF3.52:Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well‐known green emission from the ≈30 nm sized hexagonal‐phase NaYF4:Yb,Er UCNPs. By utilizing Na0.52YbF3.52:Er@SrF2UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light‐triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity (r2) and the strong X‐ray attenuation ability of Yb3+ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X‐ray computed tomography dual‐modal imaging. Our research shows the great potential of the red emitting Na0.52YbF3.52:Er UCNPs for multimodal imaging‐guided photodynamic therapy of tumors.