Trials, travails and triumphs: an account of RNA catalysis in RNase P.
Trials, travails and triumphs: an account of RNA catalysis in RNase P.
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DOI：
10.1016/j.jmb.2010.01.038
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发表时间：
2010-04
影响因子：
5.6
通讯作者：
W. McClain;Lien B. Lai;V. Gopalan
中科院分区：
文献类型：
--
作者：
W. McClain;Lien B. Lai;V. Gopalan
去年 12 月是西德尼·奥尔特曼 (Sidney Altman) 和托马斯·切赫 (Thomas Cech) 因在细菌核糖核酸酶 P（一种催化 tRNA 5' 成熟的酶）和四膜虫自剪接 rRNA 中分别发现 RNA 催化剂而获得诺贝尔化学奖 20 周年。恰逢 RNase P 论文发表1，这篇综述提供了历史叙述、对我们当前知识的简要报告，并对 RNase P 的一些研究前景进行了讨论。
Last December marked the 20th anniversary of the Nobel Prize in Chemistry to Sidney Altman and Thomas Cech for their discovery of RNA catalysts in bacterial ribonuclease P (an enzyme catalyzing 5′ maturation of tRNAs) and a self-splicing rRNA of Tetrahymena, respectively. Coinciding with the publication of a treatise on RNase P,1this review provides a historical narrative, a brief report on our current knowledge, and a discussion of some research prospects on RNase P.