Automated screening platform with isochronal-parallel analysis and conditioning for rapid method development of chiral separations
Automated screening platform with isochronal-parallel analysis and conditioning for rapid method development of chiral separations
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DOI：
10.1002/jssc.200600491
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发表时间：
2007-06-01
影响因子：
3.1
通讯作者：
Francotte, Eric
中科院分区：
文献类型：
--
作者：
Wetli, Herbert A.;Francotte, Eric
开发了一种自动化手性分离筛选平台，允许在一个柱上进行分离分析，而另一个柱同时用不同的移动的相（MP）平衡。该平台可以用普通的HPLC组件以适中的成本建立，它大大加快了筛选过程，允许在短时间内测试多种色谱条件，并在制备分离中显着增加时间和生产率。
An automated chiral separation-screening platform was developed, allowing separation analysis on one column while another column is simultaneously equilibrated with a different mobile phase (MP). The platform can be set up from usual HPLC components at moderate cost and it considerably speeds up the screening process, allowing numerous chromatographic conditions to be tested within a short period of time and leading to a significant gain in time and productivity in preparative separations.