Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice
Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice
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DOI：
10.1016/j.carbpol.2016.03.068
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发表时间：
2016-08-01
影响因子：
11.2
通讯作者：
Ifuku, Shinsuke
中科院分区：
文献类型：
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作者：
Izumi, Ryotaro;Azuma, Kazuo;Ifuku, Shinsuke
我们评估了通过皮肤拭子应用几丁质纳米纤维（CNF）对实验性特应性皮炎（AD）模型的影响。CNF治疗后AD评分较低，表皮肥大和角化过度受到抑制。此外，表皮和真皮中的炎症细胞浸润均受到抑制。 CNF 还减弱了组织学评分。 CNFs的抑制效果与皮质类固醇的应用相同；然而，甲壳素没有显示出这些效果。 CNF 的应用可能通过抑制核因子 -kappa B、环氧合酶-2 和诱导型一氧化氮合酶的激活而具有抗炎作用。在实验性 AD 的早期模型中，CNF 抑制 AD 进展的程度与皮质类固醇相同。它们还抑制皮肤炎症和 IgE 血清水平。我们的研究结果表明，CNF 的应用可以帮助预防或治疗 AD 皮肤病变。 (C) 2016 Elsevier Ltd. 保留所有权利。
We evaluated the effect of chitin nanofibril (CNF) application via skin swabs on an experimental atopic dermatitis (AD) model.AD scores were lower, and hypertrophy and hyperkeratosis of the epidermis were suppressed after CNF treatment. Furthermore, inflammatory cell infiltration in both the epidermis and dermis was inhibited. CNFs also attenuated histological scores. The suppressive effects of CNFs were equal to those of corticosteroid application; however, chitin did not show these effects. CNF application might have antiinfllammatory effects via suppression of the activation of nuclear factor -kappa B, cyclooxygenase-2, and inducible nitric oxide synthase.In an early-stage model of experimental AD, CNFs suppressed AD progression to the same extent as corticosteroids. They also suppressed skin inflammation and IgE serum levels. Our findings indicate that CNF application could aid in the prevention or treatment of AD skin lesions. (C) 2016 Elsevier Ltd. All rights reserved.