Outcome of childhood leukaemia survivors and necrosis of the femoral head treated with autologous mesenchymal stem cells
Outcome of childhood leukaemia survivors and necrosis of the femoral head treated with autologous mesenchymal stem cells
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DOI：
10.1007/s12094-017-1752-9
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发表时间：
2018-05-01
影响因子：
3.4
通讯作者：
Ramirez, M.
中科院分区：
文献类型：
--
作者：
de Rojas, T.;Martinez-Alvarez, S.;Ramirez, M.
皮质激素诱导的股骨头坏死（ON）可导致严重的髋关节损伤和髋关节置换术，对预期寿命较长的急性淋巴细胞白血病（ALL）年轻幸存者产生负面影响。我们的目标是用一种新的方法来改善这些患者的生活质量。基于间充质干细胞（MSCs）的再生能力，我们对两名患有双侧股骨ON的青少年进行了局部植入自体细胞治疗。这需要一种简单的微创手术。两名患者都经历了显着的疼痛缓解和步态运动学价值的恢复。影像学评价显示髋关节塌陷停止。我们的初步结果表明，自体骨髓间充质干细胞可以被认为是一种新的治疗儿童和年轻人的ON后，克服ALL。它可以避免髋关节置换术，提高白血病幸存者的生活质量。
Corticoid-induced osteonecrosis (ON) of femoral head can lead to severe hip joint impairment and hip replacement, with negative impact in young survivors of acute lymphoblastic leukaemia (ALL) with long life expectancy. We aim to improve quality of life in these patients with a novel approach.Based on the regenerative capacities of mesenchymal stem cells (MSCs), we performed locally implanted autologous cell therapy in two adolescents suffering of bilateral femoral ON. This required a simple, minimally invasive surgical procedure.Both patients experienced significant pain relief and restoration of gait kinematic values. Radiographic evaluation showed cessation of hip collapse. No toxicities/complications were observed after a 4-year follow-up.Our preliminary results suggest that autologous MSCs can be considered as a novel treatment for children and young adults with ON after overcoming ALL. It may avoid hip replacement and improve quality of life of leukaemia survivors.