Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus
Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus
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DOI：
10.1002/jmv.10572
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发表时间：
2004-02-01
影响因子：
12.7
通讯作者：
Kobayashi, K
中科院分区：
文献类型：
--
作者：
Ebihara, T;Endo, R;Kobayashi, K
人偏肺病毒（hMPV）是一种病毒，可诱导人呼吸道合胞病毒（hRSV）样疾病，从上呼吸道感染到严重的细支气管炎和肺炎。分别采用间接免疫荧光法和中和抗体法检测100份1个月至5岁儿童血清中hMPV和hRSV抗体的存在。4月龄以上儿童hMPV阳性率显著低于hRSV（43% vs.60%，P < 0.025），其中4月龄与1岁儿童hMPV阳性率差异显著（11% vs.48%，P = 0.006）。结果表明，hMPV的初次感染比hRSV的发生稍晚。(C)2004 Wiley-Liss，Inc.
Human metapneumovirus (hMPV) is a virus that induces human respiratory syncytial virus (hRSV)-like illnesses, ranging from upper respiratory tract infection to severe bronchiolitis and pneumonia. The 100 serum samples from children aged 1 month to 5 years were tested for the presence of hMPV and hRSV antibodies using an indirect immunofluorescence assay and a neutralizing-antibody assay, respectively. The seroprevalence of hMPV was significantly lower than that of hRSV in children over 4-months-old (43% vs. 60%, P < 0.025), and the difference was particularly notable between the ages of 4 months and 1 year (11% vs. 48%, P = 0.006). The results suggest that primary infection with hMPV occurs somewhat later than that with hRSV. (C) 2004 Wiley-Liss, Inc.