Functional Significance of Rall's Power of Three Halves Law in Cortical Nonpyramidal Cells
Functional Significance of Rall's Power of Three Halves Law in Cortical Nonpyramidal Cells
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拉尔三半幂定律在皮质非锥体细胞中的功能意义
DOI：
10.1007/978-94-007-4792-0_7
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Yoshiyuki Kubota
中科院分区：
文献类型：
--
作者：
DeFelipe J;Lopez-Cruz PL;Kawaguchi Y;Kisvarday Z;Kubota Y;Yoshiyuki Kubota
神经元在树突和索马上接受成千上万的突触输入，并在空间和时间上整合这些输入，以轴突中产生的动作电位的形式产生适当的输出。树突的形态可以影响突触输入的整合，也可以影响动作电位的模式。使用计算机模拟的三个不同的模型神经元亚型具有不同的树突尺寸相同的分支模式相同的真实的皮层中间神经元在大鼠额叶皮层：Martinotti细胞，快速尖峰篮细胞，双花束细胞，和大篮细胞，我们发现的功能意义的Rall的权力的三个一半的法律在树突分叉点。它可以促进体细胞去极化均匀分布到树突树的所有隔室中，并且它可以促进从索马到所有树突分支的相等信号传导。
Neurons receive thousands of synaptic inputs onto their dendrites and soma, and spatially and temporally integrate these inputs to produce appropriate output in the form of action potentials generated in axons. The morphology of dendrites can influence the integration of synaptic input, as well as affect the pattern of action potentials. Using computer simulations of three different model neuron subtypes with different dendritic dimension of the same branching pattern identical to the authentic cortical interneuron in the rat frontal cortex: Martinotti cell, fast spiking basket cell, double bouquet cell, and large-basket cell, we found the functional significance of Rall’s power of three halves law at the dendritic bifurcation point. It may facilitate even distribution of somatic depolarization into all compartments of the dendritic tree, and it may contribute equal signal conduction from soma to all dendritic branches.