Depression and chronic pain in the elderly: links and management challenges.
Depression and chronic pain in the elderly: links and management challenges.
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DOI：
10.2147/cia.s113576
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发表时间：
2017
影响因子：
3.6
通讯作者：
Paladini A
中科院分区：
文献类型：
--
作者：
Zis P;Daskalaki A;Bountouni I;Sykioti P;Varrassi G;Paladini A
衰老是一个不可避免的过程，代表着随着时间的推移身体变化的积累。抑郁症和慢性疼痛在老年人群中非常普遍。据估计，13%的老年人口将同时患有这两种疾病。越来越多的证据表明，神经炎症在抑郁症和慢性疼痛的发病机制中都起着关键作用。然而，除了共同的病理生理机制外，这两个实体还有几个临床联系。对于疼痛内科医生来说，他们的管理是具有挑战性的；然而，药理学和非药理学的方法都是可用的，并且可以在老年患者同时存在这两种情况时使用。
Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links. Their management is challenging for the pain physician; however, both pharmacologic and nonpharmacologic approaches are available and can be used when the two conditions are comorbid in the elderly patients.